Life Extension Enhanced Irvingia with Calorie Control Complex, 120 caps

     Public health agencies blame gluttonous behavior and lack of physical activity as the sole reasons for today’s obesity epidemic. Ignored are a plethora of age related metabolic changes that predispose us to weight gain, even when we try to cut back on caloric intake. The good news is that you don't have to go it alone. Scientists have identified natural compounds that function via multiple mechanisms to combat the underlying factors involved in excess accumulation of body fat.

New green tea phytosome

The effects of green tea polyphenols in inhibiting the breakdown and absorption of dietary fats have been demonstrated in several studies. More recent research confirms the metabolic-enhancing properties of a proprietary green tea phytosome that is absorbed into the bloodstream better than conventional green tea products. A clinical trial documents 30 pounds of weight loss and a 10% reduction in waist circumference in 90 days when 300 mg/day of this new green tea phytosome is taken in conjunction with lifestyle modification.1 The placebo group that followed the same lifestyle modification program lost only 9.9 pounds and only 5% of their waist size. This new green tea phytosome provides two important components of a comprehensive weight loss program.

Inhibiting the alpha-amylase enzyme

Aging reduces our ability to utilize the carbohydrates (and fats) that constitute what most would consider part of a healthy diet. The result is that as we grow older, our bloodstreams become chronically overloaded with glucose and triglycerides that not only make it difficult to shed fat pounds, but also create vascular problems. A proven method to maintain healthy blood glucose is to neutralize the alpha-amylase enzyme in the intestines.

A natural bean extract (Phaseolus vulgaris) inhibits alpha-amylase. In a human trial in which all overweight participants were placed on a 2,000-2,200-calorie, carbohydrate-rich diet, those taking Phaseolus vulgaris lost 6.5 pounds and 1.2 inches in waist size in only 30 days compared with 0.8 pounds and 0.2 inches in the placebo group.2

Inhibiting the alpha-glucosidase enzyme

Maintaining healthy blood glucose (and triglyceride) usually requires more than just inhibiting the alpha-amylase enzyme. Another intestinal enzyme that enables carbohydrate absorption is alpha-glucosidase. A patented seaweed extract (InSea2™) has demonstrated potent inhibiting effects against alpha-glucosidase and alpha-amylase. When given to laboratory animals, this seaweed extract reduced after-meal (postprandial) disorders by up to 90% compared with non-supplemented animals. Equally impressive were insulin reductions as much as 40% in the animals supplemented with InSea2™. Chronically elevated insulin levels, as observed in overweight and obese individuals, can preclude fat loss. Excess glucose converts to triglycerides, which is the primary form that fat is stored in the body. By consuming compounds that inhibit the glucosidase and amylase enzymes before meals, the rate of carbohydrate absorption can be significantly slowed, resulting in reduced conversion of glucose to stored body fat.

Remember, young healthy individuals rapidly convert ingested fats-sugars into energy. Age-related changes reduce our metabolic capacity to efficiently utilize dietary sugars and fats, ergo the importance of impeding their absorption to help maintain a healthy body weight in maturing individuals.

Restoring leptin sensitivity

Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough. Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes via the process of lipolysis. Heavy individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds. An extract from a West African food called Irvingia gabonensis has been shown to restore leptin sensitivity by suppressing inflammatory factors. In a recently published study, Irvingia demonstrated a marked reduction in leptin blood levels, a reduction in appetite, followed by significant loss of body weight and inches off the waistline.3 In addition to restoring leptin sensitivity, Irvingia has demonstrated the following fat-reducing mechanisms:

• Glycerol-3-phosphate dehydrogenase is the enzyme that converts blood glucose to triglycerides in fat cells. Irvingia has the unique effect of inhibiting glycerol-3-phosphate dehydrogenase,4 thus reducing the amount of blood glucose that converts to stored body fat.
• Irvingia has alpha-amylase-inhibiting properties5 (like InSea2™ and Phaseolus vulgaris), thus slowing the rate of carbohydrate absorption from the intestines.
• Adiponectin is a hormone involved in helping to maintain insulin sensitivity on the membranes of energy-producing cells. Heavy individuals have low adiponectin blood levels, which contribute to the phenomenon of insulin resistance. Irvingia has been shown to significantly increase adiponectin blood levels.4

The New Enhanced Irvingia with Calorie Control Complex

In reviewing the remarkable effects demonstrated by these natural compounds, one might think that any one of them might be a solution to one’s weight problem. The reality is that aging individuals often have many obesity factors that can sabotage the best weight-loss programs.

The new Enhanced Irvingia formula provides a combination of nutrients that combat age-related fat accumulation via the following seven distinct mechanisms:

1. Enhancing resting energy expenditure at the cellular level.
2. Impeding dietary fat absorption from the intestines.
3. Inhibiting alpha-amylase to slow intestinal carbohydrate absorption.
4. Inhibiting alpha-glucosidase to further slow intestinal carbohydrate absorption.
5. Enhancing leptin sensitivity to reduce hunger and stimulate adipocyte lipolysis.
6. Elevating adiponectin blood levels to help restore insulin sensitivity.
7. Suppressing glycerol-3-phosphate dehydrogenase to reduce the amount of blood glucose that is converted to stored fat (triglyceride) in the cells.

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

InSea2™ is a trademark of innoVactiv™
Phytosome® is a registered trademark of Indena S.P.A

This product is designed to target several critical factors involved in age-related weight gain. Those who ingest more calories than what their body has the metabolic capacity to utilize will not see results. This is because some people are ingesting so many excess calories that no matter how much their metabolic rate is increased, or how much improvement occurs in their post-meal blood sugar and serum triglyceride levels, or by how much youthful insulin sensitivity and other body fat-regulating systems are restored, they are overwhelming the metabolic capacity to utilize these calories. This will result in excess calories being stored in adipocytes. One cannot consume limitless calories and expect to shed fat pounds by taking drugs, nutrients, and/or hormones that demonstrate weight-loss effects in clinical studies.