NOW Curcumin, 665 mg, 60 Vcaps

Curcuminoid polyphenols are the primary antioxidant in turmeric root. Curcumin is the principle curcuminoid, and it is responsible for the majority of health benefits attributed to turmeric. The other curcuminoids include desmethoxycurcumin and bis-desmethoxycurcumin.

Blood sugar imbalances and insulin resistance are huge factors that promote inflammatory conditions in the body. Elevated blood sugar creates hazardous glucose cross-links with proteins, causing Advanced Glycolytic Enzymes (AGEs) to form. These AGEs damage cell membranes, vital enzyme systems and perpetuate inflammatory conditions throughout the body.

Curcumin modulates blood sugar and improves insulin receptor function by improving its binding capacity to sugar. Curcumin activates PPAR (peroxisome proliferator-activator receptor), which is a group of key nuclear proteins that regulate gene expression and modulate sugar uptake and utilization in the bloodstream. Curcumin also reduces the activity of specific liver enzymes that release sugar into the bloodstream while activating enzymes that store sugar as glycogen. Research on diabetic rats resulted in blood glucose stabilization and lowered triglyceride levels in the group that consumed curcumin.

Curcumin also reduces the activity of liver enzymes that release sugar into the bloodstream while activating enzymes that store sugar as glycogen. Research on diabetic rats resulted in blood glucose stabilization and lowered triglyceride levels in the group that consumed curcumin.Turmeric is the fourth most antioxidant-rich herb with an ORACof 159,277. The curcuminoids boost levels of the body's most potent antioxidants including glutathione, superoxide dismutase and catalase. These molecules are critical for the body to limit oxidative stress-related damage to the important organ systems.

Curcumin has been shown to reduce inflammation-mediating prostaglandins, cytokines and other molecules such as interleukin 6, nuclear factor-kappa beta (NF-kb) and tumor necrosis factor-alpha (TNF-alpha). With a high enough dosage, this has the ability to pull the body out of a strong inflammatory cascade and reset anti-inflammatory behavior at the cellular level.

Research done by the Life Extension Foundation found that curcuminoids target ten factors involved in cancer development. This includes chronic inflammation, DNA damage and disruption of cell signaling pathways. Curcumin supplementation was shown to destroy cancer cell mitochondria, disrupt the cancer cell cycle and halt stem cell development that facilitates cancer cell formation.

There are hundreds of other studies that have shown that curcumin turns on naturalcell suicide switches in cancer cells. They also reduce inflammatory prostaglandins that promote cancergrowth. A study out of China showed that curcumin was able to induce apoptosis within triple negative breast cancer cells. TNBC is a type of cancer that defies conventional chemotherapy and radiation, and is very difficult to treat.