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Item #: LEFFOL
Reg. Price: $28.00
Our Price: $21.00

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Life Extension Optimized Folate (L-Methylfolate), 1000 mcg, 100 Vcaps


Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Those who take ordinary folate supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF).

Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise blood serum folate levels compared with folic acid supplementation.

This bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active.

A study of 10 patients with endothelial dysfunction showed complete reversal of endothelial impairment after 5-MTHF supplementation compared with healthy control patients.

People with elevated homocysteine levels have a greater risk of cognitive decline. Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6, and riboflavin.

Life Extension's mission is simply to help you live a healthier, longer life. They are at the forefront of medical research, constantly looking for ways to prolong youth, health, and life. They have been at it for more than 34 years, investing more than $140 million to find therapies and technologies that could lead to lifesaving cures for the diseases of aging.

Life Extension insists on purchasing only the highest quality raw materials from all over the world, primarily from leading US, Japanese and European sources. They go one step further by using advanced analytical methods, such as high-performance liquid chromatography and gas chromatography/mass spectrometry, to ensure Their products meet label claims for potency and purity. Life Extension tests its raw materials using US Pharmacopeia and other exacting pharmaceutical assay standard.

Supplement Facts:

Serving Size: 1 vegetarian capsule

Servings Per Container: 100

Amount Per Serving:

Folate (as 5-Methyltetrahydrofolic acid (5-MTHF), and calculated based upon the biologically Active 6S isomer)

1000 mcg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), vegetable stearate, silica.

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Dosage and Use:

Take one capsule daily with food, or as recommended by a healthcare practitioner.


Healthful diets with adequate folate may reduce a woman’s risk of having a child with a brain or spinal cord defect. Women of childbearing age should consume 800 mcg of folate daily.




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