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Item #: LEFGBA
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Life Extension Optimized Resveratrol with Synergistic Grape-Berry Actives, 250mg, 60 Vcaps


Findings from published scientific literature indicate that resveratrol may be the most effective plant extract for maintaining optimal health and promoting longevity. Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by Vitis vinifera in response to attack by molds.

Life Extension has gone to great lengths to identify compounds that simulate calorie restriction’s ability to trigger youthful gene expression—the process by which genes transmit signals that slow certain aspects of aging.

For example, previous research funded by Life Extension showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract induced many of the favorable gene expression changes observed in calorie-restricted animals.

A comprehensive review of the scientific literature further revealed that certain compounds found in berries, such as pterostilbene, also possess potent “longevity gene” activators that work in synergy with resveratrol.

Life Extension's Optimized Resveratrol now features fisetin, a little-known flavonoid which is the sixth compound shown to simulate a similar youthful gene expression pattern as calorie restriction—without significant dietary modification.

In the most exciting development to date, this novel compound (fisetin) may also enhance the effects of resveratrol.

Most abundant in strawberries, fisetin has the power to “switch on” powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function. It also supports aging neurons in the presence of oxidative stress.

Most importantly, fisetin works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown3 and extending its effects.

To take advantage of this extraordinary property, Optimized Resveratrol with Synergistic Grape-Berry Actives includes fisetin, to enhance resveratrol’s beneficial action. The formula provides cutting-edge broad spectrum support for youthful gene expression from the most scientifically validated, natural sources.

Life Extension's mission is simply to help you live a healthier, longer life. They are at the forefront of medical research, constantly looking for ways to prolong youth, health, and life. They have been at it for more than 34 years, investing more than $140 million to find therapies and technologies that could lead to lifesaving cures for the diseases of aging.

Life Extension insists on purchasing only the highest quality raw materials from all over the world, primarily from leading US, Japanese and European sources. They go one step further by using advanced analytical methods, such as high-performance liquid chromatography and gas chromatography/mass spectrometry, to ensure Their products meet label claims for potency and purity. Life Extension tests its raw materials using US Pharmacopeia and other exacting pharmaceutical assay standard.

Supplement Facts:

Serving Size: 1 vegetarian capsule

Servings Per Container: 60

Amount Per Serving:

Trans-resveratrol [from Polygonum cuspidatum extract (root) and whole red grape (Vitis vinifera) extract]

250 mg

Red Grape (Full Spectrum French Red Wine Polyphenol Profile), Wild Blueberry (Vaccinium angustifolium), and Polygonum cuspidatum extract blend [supplying polyphenols, anthocyanins, OPCs, free resveratrol, resveratrol conjugates (epsilon-viniferin, trans and cis-polydatin), and resveratrol analogs (pterostilbene)]

85 mg

Quercetin (as quercetin dihydrate)

60 mg

Trans-Pterostilbene (as pure Pterospan and SMART pterostilbene)

0.5 mg

Fisetin [from (Rhus succedanea L.) extract (stem)]

10 mg

Other ingredients: vegetable cellulose (capsule), silica, vegetable stearate.

Contains yeast.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

 Same material as research trials.
Pterospan (Pure Pterostilbene) and SMART are trademarks of Pharma Science Nutrients, Inc., and are used here under license. All rights reserved worldwide.

Dosage and Use:

Take one capsule daily with or without food, or as recommended by a healthcare practitioner.


If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.




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