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Item #: LEFME120
Reg. Price: $94.00
Our Price: $70.50

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Life Extension Mitochondrial Energy Optimizer with BioPQQ, 120 capsules

Aging is characterized by inflammation, glycation and mitochondrial decay. Mitochondria are the energy-producing powerhouses of the cells and are found in highest concentrations in metabolically active organs such as the brain, heart, and skeletal muscles.

Currently, the only known strategies to generate new mitochondria are long-term, strenuous aerobic exercise or caloric restriction, which are difficult or impractical for most people to implement.

Now, Life Extension members have an alternative to counteract the age-related decline in mitochondria with the new Mitochondrial Energy Optimizer with Bio-PQQ.

Mitochondrial Energy Optimizer with Bio-PQQ is the most complete mitochondrial support formula on the market.

It contains a broad spectrum of ingredients to counteract the primary factors of aging while enhancing the ability of mitochondria to produce energy (ATP).

The newest addition, an essential micronutrient known as PQQ has actually been shown to stimulate the production of new mitochondria!

This cutting-edge formula provides nutrients to counteract mitochondrial decay (one of the primary factors of aging), nutrients to boost the mitochondrial energy-producing capacity, and now, PQQ.

Research has confirmed that PQQ’s cell-signaling effects translate to benefits for the cardiovascular, nervous, reproductive and immune systems.

Mitochondrial Energy Optimizer is designed to counteract age-related structural and functional changes by providing the following unique ingredients:

  • Carnosine — As humans age, their proteins become irreversibly damaged by lethal glycation reactions. Glycation is the cross-linking of proteins and sugar to form non-functioning structures in the body, which can lead to alterations of normal cell function.

  • Carnosine is not only the premier anti-glycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.

  • Luteolin — Unremitting systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha.

  • Luteolin is a super-potent plant extract that has been shown to suppress these dangerous inflammatory cytokines.

  • Benfotiamine — Benfotiamine blocks multiple destructive biochemical pathways, including AGEs’ formation pathway, which is induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL.

  • Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal. Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.

  • Pyridoxal 5’-phosphate — Aging results in the formation of toxic advanced glycation end products throughout the body. Pyridoxal 5’-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions.

  • R-lipoic acid — Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. The microencapsulated Bio-Enhanced R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals.
  • Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.

  • Acetyl-L-carnitine arginate — The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. ArginoCarn Acetyl-L-carnitine arginate is a patented form of carnitine that has been shown in cell cultures to stimulate the growth of neurites.

  • BioPQQ — The newest addition to Mitochondrial Energy Optimizer. While all the other nutrients in this formula support the structure or function of mitochondria, PQQ has been shown to stimulate the production of new mitochondria.

  • In humans, PQQ has been shown to support healthy levels of CRP and plasma antioxidant potential, as well as to promote memory, attention, and cognition in maturing individuals. In animals, it has demonstrated the ability to support cardiovascular, immune, neurological, and reproductive health.

  • Life Extension's mission is simply to help you live a healthier, longer life. They are at the forefront of medical research, constantly looking for ways to prolong youth, health, and life. They have been at it for more than 34 years, investing more than $140 million to find therapies and technologies that could lead to lifesaving cures for the diseases of aging.

    Life Extension insists on purchasing only the highest quality raw materials from all over the world, primarily from leading US, Japanese and European sources. They go one step further by using advanced analytical methods, such as high-performance liquid chromatography and gas chromatography/mass spectrometry, to ensure Their products meet label claims for potency and purity. Life Extension tests its raw materials using US Pharmacopeia and other exacting pharmaceutical assay standard.

  • Supplement Facts:

    Serving Size: 4 capsules

    Servings Per Container: 30

    Amount Per Serving:

    Vitamin B6 (as pyridoxal 5’-phosphate)

    100 mg


    25 mg


    1000 mg

    ArginoCarn Acetyl-L-carnitine arginate dihydrochloride

    675 mg


    150 mg

    R-Lipoic Acid (as microencapsulated Bio-Enhanced stabilized Na-RALA sodium R-lipoate)

    150 mg

    BioPQQ Pyrroloquinoline quinone disodium salt

    10 mg

    Luteolin (high purity luteolin as Pureolin)

    8 mg

    Other ingredients: gelatin, vegetable stearate, silica.

    Contains soybeans.

    Bio-Enhanced is a registered trademark of Geronova Research, Inc.
    Pureolin is a trademark of Pharma Science Nutrients, Inc., and is used here under license. All rights reserved worldwide.
    BioPQQ is a trademark of MGC (Japan).
    ArginoCarn is a registered trademark of Sigma-tau HealthSciences, Inc. and is protected by US patents 6,365,622, US 6,703,042 and EP1202956.

    Dosage and Use:

    Take two capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.


    This product can be taken with or without food.







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